 |
朱才英，青年PI，博士生导师。主要从事正常和疾病状态下的造血调控研究，先后在Nature Cell biology、Blood、Science Immunology、Cell Research等国际期刊发表SCI论文17篇，其中第一作者（含共同）2篇。参与国家重点研发计划和国家自然科学基金面上项目共5项。
学习和工作经历
2024.11 - 至今 澳门新葡萄新京威尼斯123（新葡萄娱乐官网版游戏987）青年PI
2021.09 - 2024.09 中国医学科学院血液病医院（中国医学科学院血液学研究生）博士后
2015.08 - 2021.07 北京协和医学院 博士
2011.08 - 2015.07 天津医科大学 学士
主要获奖情况
2022 协和青年学者支持计划
2022 天津市优秀博士后
课题组结合单细胞多组学、生物信息学方法和动物模型等，对正常和疾病状态下的造血调控、肿瘤耐药复发机制等开展研究。
1. Zhu C#, Lian Y#, Wang C#, Wu P#, Li X#, Gao Y, Fan S, Ai L, Fang L, Pan H, Cheng T*, Shi J*, Zhu P*. Single-cell transcriptomics dissects hematopoietic cell destruction and T-cell engagement in aplastic anemia. Blood. 2021 Jul 8; 138(1):23-33.
2. Dong F#, Hao S#, Zhang S#, Zhu C#, Cheng H#, Yang Z, Hamey FK, Wang X, Gao A, Wang F, Gao Y, Dong J, Wang C, Wang J, Lan Y, Liu B, Ema H, Tang F, Göttgens B*, Zhu P*, Cheng T*. Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis. Nat Cell Biol. 2020 Jun; 22(6):630-639.
3. An S#, Bi H#, Luo X, Zhu C, Wang M, Pang A*, Cui Y*. Identification of key genes of diabetic cardiomyopathy in hiPSCs-CMs based on bioinformatics analysis. Mol Cell Biochem. 2024 Dec; 479(12):3447-3458.
4. Huo Y#, Wu L#, Pang A#, Li Q#, Hong F#, Zhu C, Yang Z, Dai W, Zheng Y, Meng Q, Sun J, Ma S, Hu L, Zhu P, Dong F, Gao X, Jiang E*, Hao S*, Cheng T*. Single-cell dissection of human hematopoietic reconstitution after allogeneic hematopoietic stem cell transplantation. Sci Immunol. 2023 Mar 17; 8(81):eabn6429.
5. Xia J#, Liu M#, Zhu C, Liu S, Ai L, Ma D, Zhu P, Wang L*, Liu F*. Activation of lineage competence in hemogenic endothelium precedes the formation of hematopoietic stem cell heterogeneity. Cell Res. 2023 Jun; 33(6):448-463. (IF:28.1)
6. Pagliuca S#, Gurnari C#, Hercus C, Hergalant S, Nadarajah N, Wahida A, Terkawi L, Mori M, Zhou W, Visconte V, Spellman S, Gadalla SM, Zhu C, Zhu P, Haferlach T, Maciejewski JP. Molecular landscape of immune pressure and escape in aplastic anemia. Leukemia. 2023 Jan; 37(1):202-211.
7. Gao A#, Xu S#, Li Q, Zhu C, Wang F, Wang Y, Hao S, Dong F, Cheng H, Cheng T, Gong Y. Interlukin-4 weakens resistance to stress injury and megakaryocytic differentiation of hematopoietic stem cells by inhibiting Psmd13 expression. Sci Rep. 2023 Aug 31; 13(1):14253.
8. Yang S#, Sun G#, Wu P#, Chen C#, Kuang Y, Liu L, Zheng Z, He Y, Gu Q, Lu T, Zhu C, Wang F, Gou F, Yang Z, Zhao X, Yuan S, Yang L, Lu S, Li Y, Lv X, Dong F, Ma Y, Yu J, Ng LG, Shi L, Liu J*, Shi L*, Cheng T*, Cheng H*. WDR82-binding long noncoding RNA lncEry controls mouse erythroid differentiation and maturation. J Exp Med. 2022 Apr 4; 219(4):e20211688.
9. Li Y#, Tang C#, Liu F, Zhu C, Liu F, Zhu P*, Wang L*. DNA methylation safeguards the generation of hematopoietic stem and progenitor cells by repression of Notch signaling. Development. 2022; 149(10): dev200390.
10. Hu L#, Yin X#, Zhang Y#, Pang A#, Xie X, Yang S, Zhu C, Li Y, Zhang B, Huang Y, Tian Y, Wang M, Cao W, Chen S, Zheng Y, Ma S, Dong F, Hao S, Feng S, Ru Y, Cheng H, Jiang E, Cheng T. Radiation-induced bystander effects impair transplanted human hematopoietic stem cells via oxidative DNA damage. Blood. 2021 Jun 17; 137(24):3339-3350.
11. Xie M, Zhang S, Dong F, Zhang Q, Wang J, Wang C, Zhu C, Zhang S, Luo B, Wu P, Ema H. Granulocyte colony-stimulating factor directly acts on mouse lymphoid-biased but not myeloid-biased hematopoietic stem cells. Haematologica. 2021 Jun 1; 106(6):1647-1658.
12. Xie X#, Liu M#, Zhang Y#, Wang B, Zhu C, Wang C, Li Q, Huo Y, Guo J, Xu C, Hu L, Pang A, Ma S, Wang L, Cao W, Chen S, Li Q, Zhang S, Zhao X, Zhou W, Luo H, Zheng G, Jiang E, Feng S, Chen L, Shi L, Cheng H, Hao S*, Zhu P*, Cheng T*. Single-cell transcriptomic landscape of human blood cells. Natl Sci Rev. 2020 Aug 24; 8(3):nwaa180.
13. Yin X#, Hu L#, Zhang Y, Zhu C, Cheng H, Xie X, Shi M, Zhu P, Zhao X, Chen W, Zhang L, Arakaki C, Hao S, Wang M, Cao W, Ma S, Zhang X*, Cheng T*. PDGFB-expressing mesenchymal stem cells improve human hematopoietic stem cell engraftment in immunodeficient mice. Bone Marrow Transplant. 2020 Jun; 55(6):1029-1040.
14. Gao A#, Gong Y#, Zhu C, Yang W, Li Q, Zhao M, Ma S, Li J, Hao S*, Cheng H*, Cheng T*. Bone marrow endothelial cell-derived interleukin-4 contributes to thrombocytopenia in acute myeloid leukemia. Haematologica. 2019 Oct; 104(10):1950-1961.
