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何晶晶, 青年PI，博士生导师。主要研究方向为“肿瘤免疫学和肿瘤免疫治疗”，通过单细胞测序鉴定和表征肿瘤中识别肿瘤新生抗原的T细胞，并制备成个体化TCR-T细胞，开展相关临床试验。于Cell Research，Cell等期刊发表SCI论文13篇，其中第一（含共同第一）作者5篇。主持国家自然科学基金面上项目/青年项目各一项，博士后基金面上项目一项。
学习和工作经历
2024.11 -至今 新葡萄娱乐官网版游戏987，青年PI
2022 - 2024 广东省人民医院，医学研究部，特聘副研究员
2021 - 2022 广东省人民医院，医学研究部，助理研究员
2017 - 2021 中山大学肿瘤防治中心, 博士后
2013 - 2015 昆士兰大学, 细胞与分子生物学, 联合培养博士
2009 - 2017 西北农林科技大学, 动物学, 直博
2005 - 2009 西北农林科技大学, 生物技术, 学士
主要获奖情况
2022 赛诺菲-Cell Research 2022 年度杰出研究论文
2015 Pincus Taft Young Investigators Award in Australian Diabetes Society Conference
2015 Travel grant for Australian Diabetes Society Conference
2012 中国留学基金委公派联合培养博士奖学金
2008 西北农林科技大学 国家奖学金
何晶晶团队致力于肿瘤免疫学和实体肿瘤免疫治疗相关研究。
1. Jingjing He#, Xinxin Xiong#, Han Yang#, Dandan Li#, Xuefei Liu#, Shuo Li, Shuangye Liao, Siyu Chen, Xizhi Wen, Kuai Yu, Lingyi Fu, Xingjun Dong, Kaiyu Zhu, Xiaojun Xia, Tiebang Kang, Chaochao Bian, Xiang Li, Haiping Liu, Peirong Ding*, Xiaoshi Zhang*, Zhenjiang Liu*, Wende Li*, Zhixiang Zuo*, Penghui Zhou*. Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response. Cell Res, 2022; 32(6): 530–542
2. Xianwen Ren#, Wen Wen#, Xiaoying Fan#, Wenhong Hou#, Bin Su#, Pengfei Cai#, Jiesheng Li#, Yang Liu#, Fei Tang#, Fan Zhang#, Yu Yang#, Jiangping He#, Wenji Ma#, Jingjing He#, Pingping Wang#, Xinxin Xiong, Qiqi Cao, Fangjin Chen, Yuqing Chen, Xuelian Cheng, Guohong Deng, Xilong Deng, Wenyu Ding, Yingmei Feng, Rui Gan, Chuang Guo, Weiqiang Guo, Shuai He, Chen Jiang, Juanran Liang, Yi-min Li, Jun Lin, Yun Ling, Haofei Liu, Jianwei Liu, Nianping Liu, Shu-Qiang Liu, Meng Luo, Qiang Ma, Qibing Song, Wujianan Sun, GaoXing Wang, Feng Wang, Ying Wang, Xiaofeng Wen, Qian Wu, Gang Xu, Xiaowei Xie, Xudong Xing, Hao Xu, Chonghai Yin, Dongdong Yu, Kezhuo Yu, Jing Yuan, Biao Zhang, Peipei Zhang, Tong Zhang, Jincun Zhao, Peidong Zhao, Jianfeng Zhou, Wei Zhou, Sujuan Zhong, Xiaosong Zhong, Shuye Zhang, Lin Zhu, Ping Zhu, Bin Zou, Jiahua Zou, Zengtao Zuo, Fan Bai, Xi Huang, Penghui Zhou*, Qinghua Jiang*, Zhiwei Huang*, Jinxin Bei*, Lai Wei*, Xiu-Wu Bian*, Xindong Liu*, Tao Cheng*, Xiangpan Li*, Pingsen Zhao*, Fu-Sheng Wang*, Hongyang Wang*, Bing Su*, Zheng Zhang*, Kun Qu*, Xiaoqun Wang*, Jiekai Chen*, Ronghua Jin*, Zemin Zhang*.COVID-19 immune features revealed by a large-scale single cell transcriptome atlas. Cell, 2021; 184(7):1895-1913.
3. Kuai Yu#, Jingjing He#, Yongjian Wu#, Baosong Xie#, Xuefei Liu#, Bo Wei#, Haibo Zhou, Bingliang Lin, Zhixiang Zuo, Wen Wen, Wenxiong Xu , Bin Zou, Lai Wei*, Xi Huang* and Penghui Zhou*. Dysregulated adaptive immune response contributes to severe COVID-19. Cell Res, 2020; 30(9): 814 - 816.
4. Jingjing He, Daniel L Chen, Dorit Samocha-Bonet, Kevin R Gillinder, Johanna L Barclay, Graham W Magor, Andrew C Perkins, Jerry R Greenfield, Gongshe Yang*, Jonathan P Whitehead*. Fibroblast growth factor-1 (FGF-1) promotes adipogenesis by downregulation of Carboxypeptidase A4 (CPA4) - a negative regulator of adipogenesis implicated in the modulation of local and systemic insulin sensitivity. Growth Factors, 2016; 34(5–6): 210–216
5. Xiaomin Ning#, Jingjing He#, Xin’e Shi, Gongshe Yang. Regulation of Adipogenesis by Quinine through the ERK/S6 Pathway. Int J Mol Sci, 2016; 17(4): 504
6. Xiaomin Zhang , Limin Cheng , Chengqi Gao , Jing Chen , Shuangye Liao , Yongqiang Zheng , Liping Xu , Jingjing He , Danyang Wang , Ziqian Fang , Jianeng Zhang , Min Yan , Yi Luan , Siyu Chen , Li-Kun Chen , Xiaojun Xia , Chunhao Deng , Guokai Chen , Wende Li , Ze-Xian Liu# , Penghui Zhou#. Androgen Signaling Contributes to Sex Differences in Cancer by Inhibiting NF-κB Activation in T Cells and Suppressing Anti-Tumor Immunity. Cancer Res, 2023;83(6):906-921.
7. Xiaoqin Luo, Choaping Ng, Jingjing He, Mengliu Yang, Xiao Luo, Terence P Herbert, Jonathan P Whitehead*. Vitamin C protects against hypoxia, inflammation, and ER stress in primary human preadipocytes and adipocytes. Mol Cell Endocrinol, 2022;556:11740.
8. Zhenzhen Fan #, Yahui Tian #, Zhipeng Chen, Lu Liu, Qian Zhou, Jingjing He, James Coleman, Changjiang Dong, Nan Li, Junqi Huang, Chenqi Xu, Zhimin Zhang, Song Gao, Penghui Zhou*, Ke Ding*, Liang Chen*. Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors. EMBO Mol Med, 2020; 12 (6): e11571.
9. Heng Yang, Lin Xia, Jian Chen, Shuqing Zhang, Vincent Martin, Qingqing Li, Shangqing Lin, Jinfeng Chen, Joseph Calmette, Min Lu, Lingyi Fu, Jie Yang, Zhizhong Pan, Kuai Yu, Jingjing He, Eric Morand, Geraldine Schlecht-Louf, Roman Krzysiek, Laurence Zitvogel, Boxi Kang, Zeming Zhang, Andrew Leader, Penghui Zhou, Laurence Lanfumey, Minxin Shi, Guido Kroemer*, Yuting Ma*. Stress-glucocorticoid-TSC22D3 axis compromises therapy-induced antitumor immunity, Nat Med, 2019, 25(9): 1428-1441.
10. Yu-Hee Kim#, Johanna L Barclay#, Jingjing He, Xiao Luo, Hayley M O’Neill, Sarhar Keshvari, Julie A Webster, Choaping Ng, Louise J Hutley, Johannes B Prins, Jonathan P Whitehead. Identification of Carboxypeptidase X-1 (CPX-1) as a Positive Regulator of Adipogenesis. FASEB J, 2016; 30(7): 2528-40
11. Mengliu Yang, Masaki Kimura, Choaping Ng, Jingjing He, Sahar Keshvari, Felicity J Rose, Johanna L Barclay, Jonathan P Whitehead. Induction of Heme-oxygenase-1 (HO-1) does not enhance adiponectin production in human adipocytes: Evidence against a direct HO-1 – adiponectin axis. Mol Cell Endo, 2015; 413: 209-16
12. Honglei Ji, Chengchuang Song, Yuefeng Li, Jingjing He, Youlei Li, Xueli Zheng, Gongshe Yang. miR-125a inhibits porcine preadipocytes differentiation by targeting ERRα. Mol Cell Biochem, 2014; 395(1-2): 155-65.
13. Dapeng Ju, Jingjing He, Lili Zhao, Xueli Zheng, Gongshe Yang. Estrogen Related Receptor α-Induced Adipogenesis is PGC-1β-dependent. Mol Biol Rep, 2012; 39(3): 3343-54.
1. 国家自然科学基金委员会, 面上项目，82472796，转铁蛋白受体TFR1介导的铁离子内运调控CD8+T淋巴细胞活化的机制及应用，2025.01-2028.12，49万元，在研，主持。
2. 国家自然科学基金委员会,青年基金，82101860，建立靶向新冠病毒Spike蛋白的CAR-T细胞疗法，2022.01-2024.12，30万元，在研，主持。
3. 中国博士后科学基金，面上项目， 2018M643313，ABCG1在肿瘤免疫中的作用机制及其靶向作用，2019.01-2020.12，5万元，结题，主持。
4. 国家自然科学基金委员会，青年基金，81802854，高效能间皮素(Mesothelin)特异性CAR-T细胞对神经胶质母细胞瘤(GBM)治疗的应用性研究，2019.01-2021.12，21万元，结题，参与。
5. 国家自然科学基金委员会，青年基金，81802853，大麻素受体CNR2在肿瘤免疫中的作用机制及其靶向应用，2019.01-2021.12，21万元，结题，参与。
