邮箱：wudeng@muhn.edu.cn
手机：15011563197
个人简历
吴邓，男，中共党员，1988年出生，中国科学院北京基因组研究所（国家生物信息中心）博士，国家奖学金获得者，香港中文大学博士后，入选澳门新葡萄新京威尼斯123D类高层次人才，担任海南省医学会数字医学分会委员。
长期从事系统生物信息学研究，主要研究方向为衰老和衰老相关疾病的分子机制研究，特别是细胞及组织特异性衰老特征识别及其在老年各种慢性疾病中的驱动作用。共计发表SCI论文22篇，总引用超1000次（Google Scholar统计）。其中第一作者/通讯作者身份（含共同）在Aging Cell (3篇，IF=11.005)、Molecular Biology and Evolution（IF=10.7）、Autophagy（IF=13.3）、Plos Biology（IF=9.8）、Journal of Neuroinflammation（IF=9.3）、Nucleic Acids Research (IF=14.9)、Clinical and Translational Medicine (IF=10.6)等国际期刊发表SCI论文14篇，其中IF>10或者中科院1区Top的10篇。研究成果荣获“Wiley威立中国开放科学高贡献作者奖”。担任Briefings in Bioinformatics等10余家SCI杂志审稿专家。获批软件著作权1项，申请国家发明专利3项。
教育经历：
1. 2016-09至2020-07，中科院北京基因组研究所，生物信息学，博士（导师：曾长青研究员）
2. 2012-09至2015-06，哈尔滨医科大学，生物信息学，硕士（导师：王栋教授）
3. 2007-09至2012-06，哈尔滨医科大学，生物信息学，学士
工作经历：
1. 2024-10至今， 澳门新葡萄新京威尼斯123，专任教师：D类优秀人才
2. 2020-12至2024-10，香港中文大学，博士后（合作导师：Prof. Kim Hei-Man CHOW）
代表性论文（仅列第一或通讯作者身份文章，未列共同作者文章）：
1. Yueyang Zhang#, Deng Wu#（共一）, Zhen Zhang#, Jian Ma#, Shuai Jiao, Xiaolong Ma, Jiangtao Li, Yongsheng Meng, Zhixun Zhao, Haipeng Chen, Zheng Jiang, Guiyu Wang, Haiyi Liu, Yanfeng Xi, Haitao Zhou, Xishan Wang, Xu Guan. Impact of Lymph Node Metastasis on Immune Microenvironment and Prognosis in Colorectal Cancer Liver Metastasis: Insights from Multiomics Profiling. British Journal of Cancer, 2025 Jan 3. (IF= 9.082, 中科院1区)
2. Deng Wu, Xiaoman Bi, Hei-Man Chow*. Identification of female-enriched and disease-associated microglia (FDAMic) contributes to sex dimorphism in late-onset Alzheimer’s disease. Journal of Neuroinflammation, 2024 Jan 4;21(1) (IF= 9.3, 中科院1区Top)
3. Deng Wu, Jacquelyne Ka-Li Sun, Kim Hei-Man Chow*. A conserved cell cycle re-entry-senescence evolutionary trajectory in post-mitotic neurons with disease-specific signatures. Plos Biology. 2024 Apr 23;22(4):e3002559. (IF=9.8, 中科院1区Top) (Plos Biology editors' top picks for 2024)
4. Deng Wu#, Xiaoman Bi#, Peihu Li, Dahua Xu, Jianmin Qiu, Kongning Li*, Shaojiang Zheng*, Kim Hei-Man Chow*. Enhanced insulin-regulated innate monocyte phagocytic activities support extreme health span and longevity in multiple populations, Aging Cell, 2023 May;22(5):e13810 (IF=11.005, 中科院1区Top)
5. Deng Wu#, Yunao Liu#, Wei Chen*, Jianming Shao, Pubu Zhuoma, Dexiong Zhao, Yang Yu, Tianzi Liu, Ruoxuan Yu, Yongna Gan, Baima Yuzheng, Yongshu Huang, Haikun Zhang, Xiaoman Bi, Chengcheng Tao, Shujuan Lai, Qiaoxia Luo, Dake Zhang, Hongmei Wang, Pingcuo Zhaxi, Jianqing Zhang, Jie Qiao, Changqing Zeng*. How placenta promotes the successful reproduction in high-altitude populations: a transcriptome comparison between adaptation and acclimatization. Molecular Biology and Evolution, 2022 Jun 2;39(6);msac120. (IF=10.7，中科院1区Top)
6. Jacquelyne Ka-Li Sun#, Deng Wu#（共一）, Tsun-Ming Lau, Meigui Yang, Ronald P Hart, Kin-Ming Kwan, Ho-Yin Edwin Chan, Hei-Man CHOW*. Chronic alcohol metabolism results in DNA repair infidelity and cell-cycle-induced senescence in neurons. Aging Cell. 2023 Jan 23;e13772. (IF=11.005, 中科院1区Top)
7. Xu Guan#, Xiaoman Bi#, Ran Wei#, Zhixun Zhao#, Zhao Lu, Zheng Jiang, Xishan Wang*, Deng Wu* (通讯) Single-cell transcriptomic landscape reveals distinct tumorigenesis of second primary radiation-exposed rectal cancer. Clinical and Translational Medicine. 2024 Apr;14(4):e1659 (IF=10.6, 中科院1区)
8. Peihu Li#, Xiaoman Bi#, Dahua Xu#, Yuan Meng, Yucheng Xia, Jiale Cai, Yutong Shen, Jiaqi Wang, Jiazhu Chen, Lamei Yin, Bo Wang, Deng Wu*, Kongning Li*. Activation of the hypoxia response in the aging cerebrovasculature protects males against cognitive impairment. Aging Cell. 2024 Oct;23(10):e14264. (IF=11.005, 中科院1区Top)
9. Xiaoman Bi# , Dehua Zheng#, Jiale Cai#, Dahua Xu#, Liyang Chen, Zhizhou Xu, Meng Cao, Peihu Li, Yutong Shen, Hong Wang, Wuping Zheng, Deng Wu*（共同通讯）, Shaojiang Zheng*, Kongning Li*. Pan-cancer analyses reveal multi-omic signatures and clinical implementations of the forkhead-box gene family, Cancer Medicine, 2023 Aug;12(16):17428-17444. (IF: 4.0，中科院2区)
10. Dahua Xu#, Zhizhou Xu#, Xiaoman Bi#, Jiale Cai, Meng Cao, Dehua Zheng, Liyang Chen, Peihu Li, Hong Wang, Deng Wu*（共同通讯）, Jun Yang*, Kongning Li*. Identification and functional analysis of N6-methyladenine (m6A)-related lncRNA across 33 cancer types, Cancer Medicine, 2023 Jan;12(2):2104-2116. (IF: 4.0，中科院2区)
Works before 2020
1. Deng Wu#, Yan Huang#, Juanjuan Kang#, Kongning Li#, Xiaoman Bi, Ting Zhang, Nana Jin, Yongfei Hu, Puwen Tan, Lu Zhang, Ying Yi, Wenjun Shen, Jian Huang, Xiaobo Li, Xia Li*, Jianzhen Xu*, Dong Wang*. ncRDeathDB: A comprehensive bioinformatics resource for deciphering network organization of the ncRNA-mediated cell death system. Autophagy, 2015, 11(10):1917-26. (IF=13.3，中科院1区Top)
2. Yanhui Li#, Changliang Wang#, Zhengqiang Miao#, Xiaoman Bi#, Deng Wu#（共一）, Nana Jin#, Liqiang Wang, HaoWu, Kun Qian, Chunhua Li, Ting Zhang, Chunrui Zhang, Ying Yi, Hongyan Lai, Yongfei Hu, Lixin Cheng, Kwong-Sak Leung, Xiaobo Li, Fengmin Zhang, Kongning Li*, Xia Li*, Dong Wang*. ViRBase: a resource for virus–host ncRNA-associated Interactions. Nucleic Acids Research, 2015 Jan;43(Database issue):D578-82. (IF=14.9，中科院2区Top)
3. Xiaomeng Zhang#, Deng Wu#（共一）, Liqun Chen#, Xiang Li#, Jinxurong Yang, Dandan Fan, Tingting Dong, Mingyue Liu, Puwen Tan, Jintian Xu, Ying Yi, Yuting Wang, Hua Zou, Yongfei Hu, Kaili Fan, Juanjuan Kang, Yan Huang, Zhengqiang Miao, Miaoman Bi, Nana Jin, Kongning Li, Xia Li*, Jianzhen Xu*, Dong Wang*. RAID: a comprehensive resource for human RNA-associated (RNA-RNA/RNA-protein) interaction. RNA. 2014 Jul;20(7):989-93. (IF=5.636)
4. Kongning Li#, Deng Wu#（共一）, Xi Chen#, Ting Zhang, Lu Zhang, Ying Yi, Zhengqiang Miao, Nana Jin, Xiaoman Bi, Hongwei Wang*, Jianzhen Xu*, DongWang*. Current and emerging biomarkers of cell death in human disease. BioMed Research International, 2014;2014:690103. (IF=3.246)
5. Deng Wu#, Juanjuan Kang#, Yan Huang#, Xiang Li#, Xiansong Wang, Dan Huang, Yuting Wang, Bin Li, Dapeng Hao, Qi Gu, Nelson Tang, Kongning Li, Zheng Guo*, Xia Li*, Jianzhen Xu*, Dong Wang*. Deciphering global signal features of high-throughput array data from cancers. Molecular BioSystems, 2014 Jun;10(6):1549-56. (IF=4.212)
专利及软件著作权：
1. 用于抑制鼻咽癌干性分子标志物的试剂在制备鼻咽癌辅助治疗药物中的应用，2023.5.26（已受理专利）
2. 胶质瘤免疫逃逸分子标志物在胶质瘤辅助诊断和治疗中的应用，2023.2.28（已受理专利）
3. 鼻咽癌干性分子标志物在鼻咽癌辅助诊断和治疗中的应用，2023.1.18（已受理专利）
4. N6-甲基腺嘌呤相关lncRNA综合信息平台，2022SR0677015，原始取得，全部权利，2022.5.31（软件著作权）
获奖及荣誉：
1. 2023年，Wiley威立中国开放科学高贡献作者
2. 2022年，The 4th. International Conference on Aging and Cancer. Poster presentation. Second Class Award（国际会议壁报二等奖）
3. 2019年，第三届基因组医学前沿与健康普惠论坛海报评比三等奖
4. 2014年，研究生国家奖学金
